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Emergency Reversal of Clopidogrel in the Setting of Spontaneous Intracerebral Hemorrhage · World Neurosurgery. Thursday, August 11, 2011 - 16:32
ADP inhibitor reversal. (clopidogrel, ticlopedin): „check if interruption is appropriate!“ ➢ADP inhibitor reversal: ➢(no specific antidot!!!) ➢1. platelet transfusion
We postulated that NAC might reverse clopidogrel's effect on platelets. METHODS: Two groups of patients were investigated. Group 1 included 11 patients with
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The median level of platelet inhibition in the group as a whole after 5 days was 12%. The immediate reversal of clopidogrel activity requires a platelet transfusion
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reversal is required, platelet transfusion may be appropriate. 2. Elective endoscopic procedures in the patient taking clopidogrel or ticlopidine. A decision regard-
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Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Such a reversal was observed with other ester drugs, including anticancer
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These patients may be nonresponders, noncompliant, or simply not being treated with clopidogrel. It is unlikely that platelet reversal therapies
We postulated that NAC might reverse clopidogrel's effect on platelets. Methods Two groups of patients were investigated. Group 1 included 11 patients with
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Partial reversal of clopidogrel was attempted by intravenous administration of 25 mg of methyl prednisolone. Platelet closure time after 4 hours was 175 seconds
Campbell PG. Emergency reversal of clopidogrel in the setting of spontaneous intracerebral hemorrhage. World Neurosurg 76:100 (2011)
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